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Osteogenesis imperfecta can be caused by abnormally formed


A) hydroxyapatite.
B) proteoglycans.
C) collagen.
D) osteoblasts.
E) calcium.

F) A) and B)
G) A) and C)

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What chemical causes an increase in the blood calcium level?


A) growth hormone
B) vitamin D
C) sex hormones
D) calcitonin
E) parathyroid hormone

F) A) and E)
G) A) and D)

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The flat bones of the skull develop from


A) fibrous connective tissue.
B) fibrocartilage.
C) compact bone.
D) hyaline cartilage.
E) areolar tissue.

F) B) and C)
G) A) and E)

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A

Which of the following statements regarding calcium homeostasis is true?


A) When blood calcium levels are too low,osteoclast activity increases.
B) Parathyroid hormone increases calcium loss from the kidney.
C) Increased osteoblast activity increases blood calcium levels.
D) Calcitonin elevates blood calcium levels.
E) Parathyroid hormone inhibits osteoclast activity.

F) A) and E)
G) None of the above

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Osteomyelitis causes destruction of bone tissue primarily by


A) promoting inflammation and overstimulation of osteoclast activity.
B) inhibiting bone marrow production of osteoclasts.
C) suppressing the production of RANKL by osteoblasts.
D) stimulating apoptosis in osteoclast cells.

E) A) and B)
F) B) and D)

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Peter receives a blow to the front of the knee on the soccer field and collapses.The bruised bone is the ___________.

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The radiologist informs Mathew that his fracture has not penetrated the skin,meaning Mathew has a(an)


A) composite fracture.
B) open fracture.
C) irregular fracture.
D) complicated fracture.
E) closed fracture.

F) A) and B)
G) C) and D)

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Parathyroid hormone (PTH) causes


A) increased RANKL and decreased OPG.
B) PTH has no effect on RANKL and OPG.
C) increased RANKL and increased OPG.
D) decreased RANKL and decreased OPG.
E) decreased RANKL and increased OPG.

F) A) and D)
G) B) and D)

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In which type of bone would osteons be present?


A) compact bone
B) spongy bone
C) both spongy and compact

D) A) and B)
E) All of the above

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A connective tissue sheath around cartilage is the


A) periosteum.
B) ligament.
C) endosteum.
D) epiphyseal line.
E) perichondrium.

F) B) and D)
G) A) and E)

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E

Osteomyelitis is


A) a disease in adults,especially women,characterized by a reduced amount of bone matrix.
B) a disease in adults characterized by softening of bones resulting from calcium depletion.
C) a group of genetic disorders producing very brittle bones that are easily fractured; occurs because of insufficient collagen development.
D) a disease in children characterized by soft,bowed,and swollen bones.
E) bone inflammation that often results from bacterial infection.

F) A) and B)
G) C) and D)

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Name the process which changes the shapes of bones to adjust to bone stress,replaces old bone matrix and facilitates the repair of broken bone.


A) bone reabsorption
B) osteomalacia
C) appositional bone growth
D) bone remodeling

E) None of the above
F) A) and D)

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The stem cells of osteoclasts are


A) osteocytes.
B) chondrocytes.
C) monocytes.
D) osteochondral progenitor cells.
E) osteoclasts.

F) A) and D)
G) D) and E)

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C

What are the maintenance cells in bone tissue?


A) osteochondral progenitor cells
B) chondrocytes
C) osteoblasts
D) osteocytes
E) osteoclasts

F) D) and E)
G) C) and D)

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Bone remodeling may occur


A) as bones grow.
B) as bones adjust to stress.
C) as fractures heal.
D) constantly during a person's lifetime.
E) All of these choices are correct.

F) A) and E)
G) A) and B)

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The cell type that is responsible for maintaining bone once it has been formed is the


A) osteocyte.
B) chondrocyte.
C) osteoblast.
D) osteoclast.
E) chondroblast.

F) A) and B)
G) A) and C)

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Which of the following membranes covers the surface of a mature bone?


A) perichondrium
B) perimysium
C) periosteum
D) peritendineum
E) peritoneum

F) C) and D)
G) A) and B)

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Thin sheets of bone matrix are


A) lamellae.
B) lacunae.
C) trabeculae.
D) periosteum.
E) canaliculi.

F) A) and B)
G) A) and C)

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Small channels extending through the bone matrix are


A) lacunae.
B) lamellae.
C) canaliculi.
D) periosteum.
E) trabeculae.

F) D) and E)
G) A) and E)

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Interconnecting rods of bone are


A) periosteum.
B) trabeculae.
C) lamellae.
D) canaliculi.
E) lacunae.

F) A) and B)
G) A) and C)

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