Question 1

Which of the following cells is in the last nucleated stage of erythrocytic maturation? (using CAP terminology)

Accepted Answer

A)  Pronormoblast
B)  Orthochromic normoblast
C)  Polychromatophilic normoblast
D)  Basophilic normoblastE) None of the above
F) B) and C)

Question 2

Which of the following red cell inclusions are derived from denatured hemoglobin?

Accepted Answer

A)  Howell-Jolly bodies
B)  Pappenheimer bodies
C)  Heinz bodies
D)  Siderotic granulesE) B) and C)
F) None of the above

Question 3

For a red blood cell to live its full 120-day life span, which condition is necessary?

Accepted Answer

A)  The red blood cell membrane must be deformable.
B)  The red blood cell must have enough granules.
C)  The red blood cell must always remain in a round shape.
D)  There must be enough hemoglobin, regardless of function.E) A) and D)
F) B) and C) A

Question 4

The anucleate mature red blood cell has no ability to produce protein.

Accepted Answer

A) True 
 B)False

Question 5

Increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies?

Accepted Answer

A)  Spherocytes
B)  Target cells
C)  Microcytes
D)  Helmet cellsE) B) and D)
F) B) and C)

Question 6

Which red cell inclusions are remnants of DNA?

Accepted Answer

A)  Cabot rings
B)  Howell-Jolly bodies
C)  Heinz bodies
D)  Pappenheimer bodiesE) None of the above
F) All of the above B

Question 7

From each pronormoblast precursor cell, _____ mature red blood cells are produced.

Accepted Answer

A)  4
B)  8
C)  12
D)  16E) All of the above
F) A) and B)

Question 8

Which of the following electrolytes maintains its highest concentration within the red blood cell cytoplasm as opposed to circulating in the plasma?

Accepted Answer

A)  Sodium
B)  Bicarbonate
C)  Chloride
D)  PotassiumE) B) and D)
F) B) and C)

Question 9

Pappenheimer bodies are composed of which of the following components?

Accepted Answer

A)  Iron
B)  Denatured hemoglobin
C)  DNA
D)  RNAE) B) and C)
F) A) and C)

Question 10

Most hypochromic cells will have an MCHC that is _____ and are often seen in ________.

Accepted Answer

A)  greater than 36%; thalassemia
B)  less than 32%; iron-deficiency anemia
C)  greater than 27%; iron-deficiency anemia
D)  less than 27%; sideroblastic conditionsE) B) and C)
F) All of the above

Question 11

Reversible sickled cells are described as having which of the following shapes?

Accepted Answer

A)  Crescent shape with one pointed projection
B)  Crescent shape with two pointed projections
C)  Half-moon shape with rounded ends
D)  Half-moon shape with pointed projectionE) C) and D)
F) B) and D)

Question 12

Microcytic cells have MCV values of _______ and are often seen in _______.

Accepted Answer

A)  less than 90 fL; iron-deficiency anemia
B)  less than 80 fL; iron-deficiency anemia
C)  greater than 100 fL; megaloblastic anemia
D)  greater than 110 fL; megaloblastic anemiaE) A) and B)
F) None of the above

Question 13

What is the red cell protein that is responsible for deformability and flexibility of the red cell?

Accepted Answer

A)  Spectrin
B)  Glycophorin
C)  Glycine
D)  EPOE) C) and D)
F) B) and D)

Question 14

Hemoglobin begins to appear in which of the following erythrocyte stages? (listed using College of American Pathologists terminology)

Accepted Answer

A)  Basophilic normoblast
B)  Polychromatophilic normoblast
C)  Orthochromic normoblast
D)  PronormoblastE) B) and D)
F) None of the above

Question 15

When tissues become hypoxic, which of the following organs is stimulated to release erythropoietin?

Accepted Answer

A)  Pituitary gland
B)  Thyroid
C)  Pancreas
D)  KidneysE) All of the above
F) C) and D)

Question 16

Polychromatophilic macrocytes seen in the peripheral smear as a result of anemic stress are most likely which type of red blood cell?

Accepted Answer

A)  Siderocytes
B)  Reticulocytes
C)  Spherocytes
D)  Pappenheimer bodiesE) C) and D)
F) A) and D)

Question 17

When hemolysis is produced by the intravascular fragmentation of red cells, which red cell morphology may be seen in peripheral smear examination?

Accepted Answer

A)  Spherocytes
B)  Macrocytes
C)  Acanthocytes
D)  SchistocytesE) None of the above
F) A) and D)

Question 18

The degree of effective erythropoietic activity in any hematological disorder can most readily be assessed by which analysis?

Accepted Answer

A)  Red cell count
B)  Reticulocyte count
C)  M:E ratio
D)  Hemoglobin determinationE) All of the above
F) A) and D) B

Question 19

As a red blood cell matures, what is one key morphological feature of the stages containing a nucleus?

Accepted Answer

A)  Basophilic cytoplasm through every stage of maturation
B)  Granules in the cytoplasm
C)  A round nucleus
D)  An increase in size as the cell maturesE) None of the above
F) A) and D)

Question 20

The higher the N:C ratio is, the more mature the cell.

Accepted Answer

A) True 
 B)False

Exam 3: Blood Cell Production and Function and Relevant Red Cell Morphology

Which of the following cells is in the last nucleated stage of erythrocytic maturation? (using CAP terminology)

Correct AnswerverifiedShow Answer

Which of the following red cell inclusions are derived from denatured hemoglobin?

Correct AnswerverifiedShow Answer

For a red blood cell to live its full 120-day life span, which condition is necessary?

Correct AnswerverifiedA

The anucleate mature red blood cell has no ability to produce protein.

Correct AnswerverifiedShow Answer

Increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies?

Correct AnswerverifiedShow Answer

Which red cell inclusions are remnants of DNA?

Correct AnswerverifiedB

From each pronormoblast precursor cell, _____ mature red blood cells are produced.

Correct AnswerverifiedShow Answer

Which of the following electrolytes maintains its highest concentration within the red blood cell cytoplasm as opposed to circulating in the plasma?

Correct AnswerverifiedShow Answer

Pappenheimer bodies are composed of which of the following components?

Correct AnswerverifiedShow Answer

Most hypochromic cells will have an MCHC that is _____ and are often seen in ________.

Correct AnswerverifiedShow Answer

Reversible sickled cells are described as having which of the following shapes?

Correct AnswerverifiedShow Answer

Microcytic cells have MCV values of _______ and are often seen in _______.

Correct AnswerverifiedShow Answer

What is the red cell protein that is responsible for deformability and flexibility of the red cell?

Correct AnswerverifiedShow Answer

Hemoglobin begins to appear in which of the following erythrocyte stages? (listed using College of American Pathologists terminology)

Correct AnswerverifiedShow Answer

When tissues become hypoxic, which of the following organs is stimulated to release erythropoietin?

Correct AnswerverifiedShow Answer

Polychromatophilic macrocytes seen in the peripheral smear as a result of anemic stress are most likely which type of red blood cell?

Correct AnswerverifiedShow Answer

When hemolysis is produced by the intravascular fragmentation of red cells, which red cell morphology may be seen in peripheral smear examination?

Correct AnswerverifiedShow Answer

The degree of effective erythropoietic activity in any hematological disorder can most readily be assessed by which analysis?

Correct AnswerverifiedB

As a red blood cell matures, what is one key morphological feature of the stages containing a nucleus?

Correct AnswerverifiedShow Answer

The higher the N:C ratio is, the more mature the cell.

Correct AnswerverifiedShow Answer

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A

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B

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Most hypochromic cells will have an MCHC that is _ and are often seen in ____.

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Microcytic cells have MCV values of _ and are often seen in _.

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B

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