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Sweat can cause damage to bacteria because it contains salt and lysozyme.

A) True
B) False

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The third line of defense against infecting microbes is called (adaptive/innate/natural) immunity.

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In a process called (cytokinesis/hematopoiesis/hematocrit), blood stem cells located in the bone marrow produce the three types of formed elements found in the blood.

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Inflammation is an important part of the bodyʹs first line of defense, and it involves migration of phagocytes to the area.

A) True
B) False

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What do the nasal cavity, mouth, and urinary system have in common?


A) The outer layers remain intact for many days.
B) They are lined with mucous membranes.
C) They are lined with tightly packed dead cells.
D) They have roles in excretion of waste products.
E) They are poorly vascularized.

F) A) and B)
G) A) and C)

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Fever is beneficial during viral infection because the higher temperature


A) prevents viral infection of fibroblasts.
B) denatures viral proteins.
C) results in virus being shed in sweat.
D) increases vasodilation, bringing more leukocytes to the site of infection.
E) increases the effectiveness of interferons.

F) B) and C)
G) All of the above

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Neutrophils can kill bacteria by nonphagocytic mechanisms.

A) True
B) False

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Phagocytes can directly detect microbial molecules like LPS and peptidoglycan by means of


A) the complement cascade.
B) toll-like receptors.
C) bradykinin binding.
D) interferon receptors.
E) PAMPs.

F) C) and D)
G) B) and D)

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The alternative pathway for complement activation is more effective than the classical pathway.

A) True
B) False

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Which of the following statements is TRUE of eosinophils?


A) They are in intact skin, sebum, tears, etc.
B) They produce the coating of a pathogen by complement.
C) They secrete toxins onto the surface of helminth parasites.
D) They release prostaglandins and leukotrienes in response to microbes.
E) They decline during allergic reaction.

F) B) and E)
G) A) and E)

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Neutrophils produce , which can be triggered by sugar molecules on the surface of microbes to damage the microbes.


A) interferons
B) TLRs
C) antimicrobial peptides
D) NOD proteins
E) C3 and C5

F) None of the above
G) A) and E)

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The growth of some microbes is inhibited by elevated body temperature.

A) True
B) False

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Some toll-like receptors (TLRs) are found in phagosome membranes and bind forms of nucleic acids. Discuss how these TLRs and their location can play a role in the response to viral infection. (You may have to recall information from one or more previous chapters.)

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When viral particles are bound and engul...

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Which complement protein is the key to activating the alternative pathway of complement activation?


A) C1
B) C2
C) C3
D) C4
E) C5

F) A) and D)
G) All of the above

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The leukocytes called natural killer lymphocytes


A) are nonspecific leukocytes that secrete toxins onto the surface of virally infected cells.
B) increase in allergies and helminth infection.
C) release prostaglandins and leukotrienes in response to microbes.
D) are specialists in killing bacteria.
E) respond to the coating of a pathogen by complement.

F) B) and E)
G) B) and C)

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The surface of the skin serves as a barrier to microbial invasion in part because it is


A) constantly patrolled by neutrophils.
B) an acidic, high-salt environment.
C) a high-salt environment.
D) acidic.
E) moisturized by mucus secretions.

F) B) and D)
G) A) and C)

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What is the function of NK cells?


A) They phagocytose virus particles.
B) They release defensins to damage bacteria.
C) They identify and poison virus-infected cells.
D) They release toxins to damage helminth parasites.
E) They release interferons in response to detecting virus particles.

F) None of the above
G) B) and C)

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Lectins specific for mannose can lead to attack on fungi by


A) macrophages.
B) complement.
C) NK cells.
D) basophils.
E) neutrophils.

F) C) and D)
G) B) and D)

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Mucous membranes are quite thin and fragile. How can such delicate tissue provide defense against microbial invaders?


A) The mucus contains a variety of antimicrobial chemicals and molecules.
B) Both the mucus and the outer layer of cells are shed frequently.
C) The mucus secreted by the mucous membrane physically traps microbes.
D) The mucus is a physical trap that contains a variety of antimicrobial chemicals.
E) The mucus physically traps microbes, contains a variety of antimicrobial chemicals, and is shed constantly, along with the outermost layer of cells.

F) D) and E)
G) A) and B)

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Histamine and prostaglandins are involved in inflammatory reactions.

A) True
B) False

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