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What is the role of carbonic anhydrase in the kidneys?


A) It drives the recovery of HCO3- and excretion of H+.
B) It is the catalyst for the hamburger phenomenon.
C) It promotes the excretion of CO2 in the urine.
D) It promotes the loss of fluids in congestive heart failure.

E) C) and D)
F) A) and C)

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By comparison, how much fixed acid is produced in any given period compared to the volatile acid CO2?


A) about the same amount
B) less fixed than volatile
C) more fixed than volatile

D) B) and C)
E) A) and B)

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What are the major mechanisms responsible for maintaining a stable pH despite massive CO2 production? I.isohydric buffering II.gastrointestinal secretion III.pulmonary ventilation


A) II and III
B) I and II
C) I, II, and III
D) I and III

E) A) and B)
F) C) and D)

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Based on the following ABG results, what is the most likely acid-base diagnosis? pH = 7.43, PCO2 = 39 mm Hg, HCO3- = 25.1 mEq/L


A) acid-base status within normal limits
B) fully compensated metabolic acidosis
C) fully compensated respiratory alkalosis
D) partially compensated metabolic acidosis

E) None of the above
F) All of the above

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What is a normal response of the body to a failure in one component of the acid-base regulatory mechanism?


A) autoregulation
B) compensation
C) correction
D) homeostasis

E) A) and C)
F) B) and C)

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What affect does hyperventilation have on HCO3- recovery in the kidneys?


A) less H+ excretion, greater HCO3- loss
B) no affect as these involve two independent systems
C) vicious cycle of worsening alkalemia as hyperventilation stimulates increased HCO3-retention
D) escalating retention of other buffer bases along with HCO3-

E) B) and C)
F) A) and B)

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In acute respiratory acidosis, what would you expect the BE range to be?


A) -4 to -6 mEq/L
B) +2 to -2 mEq/L
C) +4 to +6 mEq/L
D) +22 to +26 mEq/L

E) B) and D)
F) B) and C)

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What is the most common cause of respiratory alkalosis?


A) anxiety
B) central nervous system depression
C) hypoxemia
D) pain

E) A) and B)
F) None of the above

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Correction of acute respiratory acidosis is accomplished by which of the following?


A) increasing HCO3-reabsorption
B) increasing alveolar ventilation
C) decreasing HCO3-reabsorption
D) decreasing alveolar ventilation

E) B) and C)
F) None of the above

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Which of the following is NOT a cause of metabolic alkalosis?


A) diuretics
B) hyperkalemia
C) hypochloremia
D) vomiting

E) None of the above
F) A) and B)

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Which of the following is a volatile acid of physiologic significance?


A) hydrochloric
B) carbonic
C) phosphoric
D) lactic

E) A) and D)
F) A) and C)

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Correction of metabolic alkalosis may involve which of the following? I.restoring normal fluid volume II.administering acidifying agents III.restoring normal K+ and Cl- levels


A) III only
B) I and II
C) II and III
D) I, II, and III

E) A) and B)
F) B) and C)

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A patient with Kussmaul's respirations most likely has:


A) metabolic acidosis
B) metabolic alkalosis
C) respiratory acidosis
D) respiratory alkalosis

E) All of the above
F) A) and B)

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If the blood PCO2 is high, the kidneys will do which of the following?


A) excrete more H+ and reabsorb more HCO3-
B) excrete less H+ and reabsorb more HCO3-
C) excrete less H+ and reabsorb less HCO3-
D) excrete more H+ and reabsorb less HCO3-

E) None of the above
F) B) and C)

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What would be an example of an iatrogenic cause of metabolic alkalosis?


A) gastric suction
B) hypochloremia
C) hypokalemia
D) vomiting

E) B) and D)
F) B) and C)

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Compensation for metabolic acidosis occurs through which of the following?


A) increase in blood CO2 levels
B) decrease in blood CO2 levels
C) decrease in blood HCO3- levels
D) increase in blood HCO3- levels

E) C) and D)
F) B) and D)

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According to the Henderson-Hasselbalch equation, the pH of the blood will be normal as long as the ratio of HCO3- to dissolved CO2 is which of the following?


A) 10:1
B) 20:1
C) 24:1
D) 30:1

E) A) and C)
F) A) and D)

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Based on the following ABG results, what is the most likely acid-base diagnosis? pH = 7.01, PCO2 = 71 mm Hg, HCO3- = 16.3 mEq/L


A) acute metabolic acidosis
B) acute respiratory acidosis
C) combined respiratory and metabolic acidosis
D) partially compensated respiratory acidosis

E) None of the above
F) A) and B)

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What is the limiting factor for H+ excretion in the renal tubules?


A) excessive amounts of Cl-
B) excessive amounts of HCO3-
C) insufficient buffers
D) insufficient sodium

E) A) and B)
F) A) and C)

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Using the Henderson-Hasselbalch equation, determine the accuracy of the gas below. To be considered accurate, it must be within 0.03 pH unit.pH = 7.35, PCO2 = 77 mm Hg, HCO3- = 41 mEq/L


A) This gas is completely accurate.
B) This gas is accurate as the calculated pH is 7.32.
C) This gas is accurate as the calculated pH is 7.38.
D) This gas is inaccurate according to the H-H equation.

E) A) and B)
F) C) and D)

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