Question 1

Which of the following represents embryonic hemoglobins formed only in the embryonic stages of human development?

Accepted Answer

A)   (22) 
B)   (22) 
C)   (22) 
D)   All of the above
E)   None of the aboveF) All of the above
G) A) and C)

Question 2

Which of the following may be found on the hemoglobin electrophoretic pattern for sickle cell anemia?

Accepted Answer

A)   No HbA (0%) 
B)   80-100% HbS
C)   1-20% HbF
D)   2-4% HbA2
E)   All of the aboveF) C) and D)
G) A) and D)

Question 3

The most significant cause of death during early childhood is the severe overwhelming septicemia and meningitis due to what organism?

Accepted Answer

A)   Rubeola
B)   Streptococcus pneumoniae
C)   Cytomegalovirus
D)   Histoplasma capsulatum
E)   Staphylococcus aureusF) B) and D)
G) None of the above

Question 4

Which of the following is characteristic of the peripheral blood smear in hemoglobin SC disease?

Accepted Answer

A)   Target cells
B)   Folded red cells
C)   Occasional glove-shaped intracellular
D)   Normocytic normochromic anemia
E)   All of the aboveF) A) and E)
G) B) and D)

Question 5

Which of the following represent(s)  inherited high-affinity hemoglobins?

Accepted Answer

A)   Hb Chesapeake
B)   Hb Rainier
C)   Hb Bethesda
D)   Hb Hiroshima
E)   All of the aboveF) A) and D)
G) B) and D)

Question 6

Which of the following describes dactylitis, which commonly occurs in infants and young children with sickle cell anemia?

Accepted Answer

A)   Microinfarction of small bones
B)   Unequal bone growth
C)   Painful swelling of the hands and feet
D)   Any of the above
E)   None of the aboveF) B) and E)
G) None of the above

Question 7

Which of the following is characteristic of hemoglobin D disease?

Accepted Answer

A)   Most common variant in American blacks is HbD Punjab (HbD Los Angeles) 
B)   Less than 0.02% frequency in American blacks
C)   Both homozygous and heterozygous states are asymptomatic
D)   Peripheral blood smear is unremarkable, except for a few target cells
E)   All of the aboveF) A) and E)
G) A) and C)

Question 8

Hemoglobin C disease is found almost exclusively in which population?

Accepted Answer

A)   Caucasian
B)   Black
C)   Asian
D)   Oriental
E)   All of the aboveF) A) and E)
G) B) and D)

Question 9

Which of the following is characteristic of the vaso-occlusive or painful crisis in a patient with sickle cell anemia?

Accepted Answer

A)   Severe pain
B)   Tissue damage and necrosis
C)   Regional hypoxia and acidosis
D)   Dehydration or exposure to extreme cold
E)   All of the aboveF) C) and E)
G) A) and B)

Question 10

Which of the following represents globin chains that may combine with alpha chains to form a particular hemoglobin?

Accepted Answer

A)   Beta () 
B)   Gamma () 
C)   Delta () 
D)   Epsilon () 
E)   All of the followingF) All of the above
G) B) and C)

Question 11

Which of the following amino acid substitution occurs in hemoglobin S?

Accepted Answer

A)   Valine for glutamic acid
B)   Glutamic acid for valine
C)   Lysine for glutamic acid
D)   Glutamic acid for lysine
E)   None of the aboveF) All of the above
G) C) and D)

Question 12

Which of the following is characteristic of the hemoglobin electrophoresis at alkaline pH for hemoglobin SC disease?

Accepted Answer

A)   50% HbS
B)   50% HbC
C)   
D)   All of the above
E)   None of the aboveF) A) and B)
G) B) and C)

Question 13

Which of the following may be found on the hemoglobin electrophoresis at alkaline pH?

Accepted Answer

A)   95% HbC plus HbA2
B)   No HbA (0%) 
C)   Less than 7% HbF
D)   All of the above
E)   None of the aboveF) None of the above
G) A) and E)

Question 14

Which of the following remains the major cause of morbidity and mortality in patients with sickle cell anemia?

Accepted Answer

A)   Serious bacterial infections
B)   Renal papillary necrosis
C)   Bone marrow aplasia
D)   Infarctions
E)   CardiomegalyF) B) and D)
G) A) and B)

Question 15

Which of the following is not characteristic of hemoglobin D disease?

Accepted Answer

A)   Migrates electrophoretically in same position as hemoglobin S
B)   Less than 0.02% frequency in American blacks
C)   Both homozygous and heterozygous states are asymptomatic
D)   Peripheral blood smear is unremarkable, except for a few target cells
E)   Positive tube solubility testF) All of the above
G) None of the above

Question 16

Which of the following can precipitate or promote sickling of red blood cells?

Accepted Answer

A)   Decrease in oxygenation
B)   Decrease in pH
C)   Dehydration
D)   All of the above
E)   None of the aboveF) B) and C)
G) A) and E)

Question 17

Which abnormal hemoglobin migrates in the same position as HbA2 on hemoglobin electrophoresis at alkaline pH?

Accepted Answer

A)   HbF
B)   HbC
C)   HbS
D)   HbG
E)   HbDF) C) and D)
G) D) and E)

Question 18

Which of the following cannot be used as a screening test for hemoglobin S in newborns?

Accepted Answer

A)   Tube solubility tests
B)   Sodium metabisulfite sickle prep
C)   Hemoglobin electrophoresis
D)   A and C
E)   A and BF) B) and E)
G) A) and D)

Question 19

Which of the following hematological results will suggest an individual with sickle cell trait?

Accepted Answer

A)   Peripheral blood smear is normal with the exception of target cells
B)   Solubility screening tests are positive
C)   Hemoglobin electrophoresis demonstrates hemoglobin A, hemoglobin S, and usually slightly elevated hemoglobin A2
D)   Sickle cells present on the peripheral smear
E)   A, B, and CF) D) and E)
G) A) and D)

Question 20

What hemoglobin(s)  is/are present in sickle cell trait?

Accepted Answer

A)   HbA2
B)   HbS
C)   HbA
D)   A and B
E)   B and CF) C) and D)
G) A) and E)

Exam 11: Hemolytic Anemias: Intracorpuscular Defects: III the Hemoglobinopathies

Which of the following is characteristic of the peripheral blood smear in hemoglobin SC disease?

Correct AnswerverifiedShow Answer

Which of the following may be found on the hemoglobin electrophoresis at alkaline pH?

Correct AnswerverifiedShow Answer

Which of the following is characteristic of the hemoglobin electrophoresis at alkaline pH for hemoglobin SC disease?

Correct AnswerverifiedShow Answer

Which of the following is characteristic of hemoglobin D disease?

Correct AnswerverifiedShow Answer

Which of the following amino acid substitution occurs in hemoglobin S?

Correct AnswerverifiedShow Answer

Which of the following describes dactylitis, which commonly occurs in infants and young children with sickle cell anemia?

Correct AnswerverifiedShow Answer

Which of the following represents globin chains that may combine with alpha chains to form a particular hemoglobin?

Correct AnswerverifiedShow Answer

Which of the following cannot be used as a screening test for hemoglobin S in newborns?

Correct AnswerverifiedShow Answer

Which of the following is not characteristic of hemoglobin D disease?

Correct AnswerverifiedShow Answer

Which of the following hematological results will suggest an individual with sickle cell trait?

Correct AnswerverifiedShow Answer

Hemoglobin C disease is found almost exclusively in which population?

Correct AnswerverifiedShow Answer

Which of the following can precipitate or promote sickling of red blood cells?

Correct AnswerverifiedShow Answer

Which of the following represents embryonic hemoglobins formed only in the embryonic stages of human development?

Correct AnswerverifiedShow Answer

Which of the following may be found on the hemoglobin electrophoretic pattern for sickle cell anemia?

Correct AnswerverifiedShow Answer

Which of the following remains the major cause of morbidity and mortality in patients with sickle cell anemia?

Correct AnswerverifiedShow Answer

What hemoglobin(s) is/are present in sickle cell trait?

Correct AnswerverifiedShow Answer

The most significant cause of death during early childhood is the severe overwhelming septicemia and meningitis due to what organism?

Correct AnswerverifiedShow Answer

Which abnormal hemoglobin migrates in the same position as HbA2 on hemoglobin electrophoresis at alkaline pH?

Correct AnswerverifiedShow Answer

Which of the following is characteristic of the vaso-occlusive or painful crisis in a patient with sickle cell anemia?

Correct AnswerverifiedShow Answer

Which of the following represent(s) inherited high-affinity hemoglobins?

Correct AnswerverifiedShow Answer

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Which abnormal hemoglobin migrates in the same position as HbA₂ on hemoglobin electrophoresis at alkaline pH?

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